- Hypersensitivity to the pantoprazole, levosulpiride or any other excipients of the formulation.
- Pheochromocytoma as it can cause hypertensive attack probably due to release of catecholamine from tumor; such attacks can be controlled with phentolamine.
- Epilepsy, manic states such as in the manic phase of manic depressive psychosis.
- Concomitant prolactin dependent tumors like pituitary gland prolactinomas and breast cancer.
- Pregnancy and lactation.